Grapefruit juice affects certain statins more than others. It depends entirely upon the medication you are. But to be on the safe side, check with your doctor, and avoid taking your pills with grapefruit juice. The majority of medications advise against drinking alcohol, and some advise against grapefruit (e.g. What's more, eating half a grapefruit is even less risky than drinking grapefruit juice, since it takes several fruits to make a single glass of juice. In terms of the actual juice, some studies have shown that less than one cup (240 mL) of 100 grapefruit juice can cause an interaction. Several sources report eating as little as one grapefruit can cause issues. Statin medications to help cholesterol, such as Lipitor or Crestor, are.
That's because the studies showing dangerous effects used massive amounts of furanocoumarins, the amount found in a quart or more of the juice. However, how much grapefruit juice one needs to consume to produce a clinically significant drug interaction isn't entirely known. alcohol used grapefruit juice to hide the taste of the ethanol.
But if you can't switch, experts say it's probably okay to enjoy a small glass. Not all statins are affected equally by grapefruit juice, so grapefruit fans might want to switch to a statin that's less affected (see the table below). This can raise your risk of side effects, like muscle pain or weakness. To be safe, I would stay away from grapefruit all. The effect of the grapefruit can last up to five hours. Grapefruit can increase the potency of many drugs (including simvastatin) from the normal dose up to 4 to 5 times of the dosage. Grapefruit and grapefruit juice can increase the amount of atorvastatin in the body. If the flavor is artificial then it would probably be ok to drink but again check with the pharmacist. Rosuvastatin does not interact with grapefruit juice or products to the same extent as atorvastatin. People of Asian descent may be more sensitive to the effects of rosuvastatin. But, drinking alcohol may worsen their potential side effects for people with certain medical conditions. Rosuvastatin is effective at lowering cholesterol however, its use may be limited by side effects such as muscle pain. As a result, more of the drug is absorbed, making it more powerful than it's meant to be - even toxic in some cases. Keep in mind that this list doesn’t include all possible atorvastatin interactions. Statins are the most widely used drugs to help lower cholesterol. Grapefruit juice contains compounds called furanocoumarins that stop CYP3A from doing its job. Why?Ī: Certain classes of drugs - most notably statins - are metabolized (broken down) in your intestines by an enzyme called CYP3A, which normally reduces the amount of drug that enters your bloodstream. Q: I've heard that people shouldn't drink grapefruit juice if they're taking a statin.
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